Endocrine Abstracts

Introduction: Obesity today is a growing epidemic throughout the world. With weight gain, the risk of type 2 diabetes and hypertension increases. With the approval of GLP-1 RA (semaglutide) by the FDA in June 2021 for weight reduction, a big push was given regarding the possibilities of obesity and especially for people at high risk of developing type 2 diabetes.Aim: To analyze the impact of semaglutide on insulin resistance and weight loss in patients w...

Abstract unavailable....

Introduction: Obesity is a cause of erectile dysfunction (ED) whereas its relationship with male infertility is more conflicting. The term metabolically healthy obesity (HO) has been used to describe an obese phenotype that does not have the burden of any metabolic disorder. The aim of the present study is to analyse the contribution of HO in the pathogenesis of ED and male infertility and to verify the value of HO in predicting major adverse cardiovascular events (MACE).<...

Background: Congenital Adrenal Hyperplasia (CAH) requires exogenous steroid replacement and can be monitored with 17-OH Progesterone and Androstenedione. We reviewed real world data to evaluate these markers in relation to hydrocortisone dose in patients treated in 21 centres throughout 14 countries.Method: Retrospective cohort study using pseudonymised data from patients with 21α-Hydroxylase Deficiency recorded in the International Congenital Adren...

Graves’ disease is a common autoimmune disease causing hyperthyroidism. Thyroid has a catabolic effect on carbohydrate metabolism especially in the hyperthyroid state. We describe a rare complication of thyrotoxicosis in a patient with type II diabetes on insulin, with no previous thyroid history. An 83 year old woman with type 2 diabetes on biphasic insulin presented with symptoms of polyuria, polydipsia and fatigue. She was tachycardic and tachypneic but normotensive an...

Graves’ disease is the most common cause of hyperthyroidism. It is well established that hyperthyroidism promotes a hypermetabolic state characterized by increased resting energy expenditure, increased lipolysis and gluconeogenesis. We describe a rare complication of thyrotoxicosis in a patient with type II diabetes on insulin, with no previous thyroid history. An 83 year old woman with type 2 diabetes on biphasic insulin presented with symptoms of polyuria, polydipsia a...

Introduction: There is no unified approach in clinical practice regarding the medical management of congenital adrenal hyperplasia (CAH), despite existent international guidance. We aimed to explore geographical and temporal variations in the treatment with glucocorticoids and mineralocorticoids of patients with CAH.Methods: We collected data recorded by 33 centres from 16 countries in the I-CAH Registry. We analysed patient visits between 1982 and 2018,...

Background: In 2019, the International CAH Registry (I-CAH) performed a benchmarking exercise of acute adrenal insufficiency related adverse events including adrenal crises (AC) and sick day episodes (SDE).Methods: In 2022, I-CAH data on children aged <18 years at first visit with 21-hydroxylase deficiency CAH from 35 centres in 19 countries were analysed to examine the current occurrence of SDE and AC and compared t...

Over the 10 percentage of all intracranial tumors are pituitary tumors.Their malignicity depends on their localisation, meanwhile their biological nature is benign. Regarding the size there are microadenomas (smaller than 10 milimeters) and macroadenomas (10 milimeters or more).Clinical manifestations of pituitary tumors depend on their localisation and hormonal activity. They are either hormonally functional or nonfunctional, resp...

Introduction: Hyponatremia is the most common electrolyte disorder in clinical practice, and evidence to date indicates that severe hyponatremia is associated with increased morbidity and mortality. The aim of our study was to perform a comprehensive meta-analysis that included all the published studies that compared mortality rates in subjects with or without hyponatremia of any degree.Methods: An extensive Medline, Embase, and Cochrane search was perfo...